CHANGELOG

v2.1.0-beta

[IMPROVEMENT] Major performance improvement in the backend API to speedup some queries

BREAKING CHANGES: Now, tbep-backend@1.3.0 is needed to function properly.

[FEATURE] Added OpenTargets portal like heatmap to TBEP.
[FEATURE] Added Data Commons module for uploading gene counts, metadata, and contrasts.
[FEATURE] Introduced PCA plots, multi-gene expression plots, and interactive volcano plots for DE analysis.

[DOCS] Updated documentation for Target Prioritization Factors, GDA, and Genetics to clarify data sources and formats.

[BUG] Fixed the issue of reported bug where 2nd order of MAPT doesn’t show GSK3B but same configuration network of GSK3B shows MAPT.
[BUG] Fixed the issue where utilizing various features doesn’t update the network view properly when used with searchbox input.

[BUG] Fixed the issue where unexpectedly bordered genes loose its bordered ring when Hub Genes feature is being used.
[IMPROVEMENT] Disease dropdown search algorithm improved to show the most relevant diseases at the top of the list.
[IMPROVEMENT] Now, result table stays in the sorting order of the searchbox input.
[FEATURE] Now, users can upload P-Value data in CSV format to the tool. It can detect case-insensitive prefix like p-val, p_value, p val etc.

[FEATURE] Added autofill seed genes based on overall association scores from the Open Targets platform to help users quickly start analysis with top-ranked genes.
[BUG] Fixed the issue where for chromium (Chrome, Edge, Brave etc.) users, the bounding box was not being cleared properly.
[BUG] Fixed the issue where even upon hiding a cluster, the nodes of the cluster were being highlighted when visible when they shouldn’t have been.

[FEATURE] Introduced feedback system with the ability to view all submitted feedback.
[IMPROVEMENT] Enhanced export system: exporting to CSV now includes gene universal data along with their interaction data (edges).
[REVERT] Removed the FunPPI database from the protein-protein interactions section for now.
[FEATURE] Added BioGrid & IntAct databases to the protein-protein interactions type section.

[FEATURE] Added History panel on the right side of the user input page to view recent interactions.
[IMPROVEMENT] Added logo to the main UI for improved branding and user experience.
[IMPROVEMENT] Enabled multiple pathway selection from the left sidebar for enhanced navigation and usability.